Retrospective Comparison of Physician-guided Tacrolimus Dosing versus Parabolic Personalized Dosing.
Project Description: Tacrolimus is often the backbone of an immunosuppressive cocktail to prevent rejection and maintain graft function in solid organ transplant recipients. Tacrolimus is a narrow therapeutic index drug whose dosing relies on therapeutic drug monitoring to avoid rejection or medication-related toxicities. Standard practice for dose adjustments is highly variable between institutions. There is significant interpatient variability in tacrolimus pharmacokinetics leading to high potential for levels not within goal. Models, such as population pharmacokinetics, physiology-based pharmacokinetics, genetics and estimative forcasting, exist to aid in tacrolimus dosing. However, accuracy is variable especially among complex, dynamic patients. Current UF Shands tacrolimus dosing is provider guided based on patient-specific pharmacokinetics.
QPI: Michelle, Estevez, (Michelle.estevez@UCDenver.edu)
Advisors: Joelle, Nelson, (firstname.lastname@example.org); (Ali.Zarrinpar@surgery.ufl.edu)
UF Health Big Aims: Reduce Variation None
MeSH Keywords: Tacrolimus, Prograf, Parabolic personalized dosing, PPD