Project Information

Evaluation of rabbit antithymocyte globulin use in solid organ transplant recipients at UF Health Shands Hospital

Project Description: Rabbit antithymocyte globulin (rATG), a purified polyclonal immunoglobulin, is a high cost, high impact medication used at UF Health Shands for both induction therapy and as treatment for acute rejection in solid organ transplant. Current use at UF Health Shands Hospital is not standardized as this medication is available via various order sets and individual orders in the electronic health record. This lack of standardization leads to possible medication errors in the areas of ordering, dispensing, and administration. Without standardization, rATG can lead to significant adverse effects, such as immune-mediated reactions, infusion-associated reactions, hematologic effects, and infection. This project will summarize the current practices in ordering, dispensing, and administration of rATG in solid organ transplant at our institution, with the goal of identifying areas for standardization via a universal order set to minimize errors.

QPI: Sara, Sterling, (

Collaborators: Joelle, Nelson, (; Tara, Veasey, (

Advisors: Joelle, Nelson, (; Tara, Veasey, (

UF Health Big Aims: Reduce Variation None

MeSH Keywords: Graft Rejection, Solid Organ Transplantation, acute rejection, induction, rabbit antithymocyte globulin, solid organ transplant