Project Information

Cardiac Arrest Database

Project Description: Cardiac arrest is the cessation of cardiac mechanical activity resulting in the absence of circulating blood flow. Cardiac arrest stops blood from flowing to vital organs, depriving them of oxygen, and, if left untreated, results in death. Cardiac arrest causes global ischemia with consequences at the cellular level that adversely affect organ function after resuscitation. The main consequences involve direct cellular damage and edema formation. Edema is particularly harmful in the brain, which has minimal room to expand, and often results in increased intracranial pressure and corresponding decreased cerebral perfusion post-resuscitation. A significant proportion of successfully resuscitated patients have short-term or long-term cerebral dysfunction manifested by altered alertness (from mild confusion to coma), seizures, or both. Survival to hospital discharge, particularly neurologically intact survival, is a more meaningful outcome than simply return of spontaneous circulation. Only about 10% of all cardiac arrest survivors have good CNS function at hospital discharge. Postresuscitative care, including circulatory support, access to cardiac catheterization, and targeted temperature management (avoidance of hyperthermia) are factors that can influence outcome post-cardiac arrest. We intend to prospectively collect variables to understand factors that influence outcome of post-cardiac arrest patients and if there are improvements that can me implemented to increase the percentage of patients that are discharged with favourable outcomes.

QPI: Sarah, Gul, (

Collaborators: Torben, Becker, (

Advisors: Joseph, Tyndall, (

UF Health Big Aims: Transform our Culture None

MeSH Keywords: Out-of-Hospital Cardiac Arrest, in-hospital cardiac arrest, traumatic cardiac arrest, OHCA, post-cardiac arrest, anoxic brain injury