Project Information

Vaccination in patients undergoing splenectomy and splenic embolization

Project Description: Patients with splenic dysfunction or asplenia are at risk for infection with encapsualated organisms and have an increased risk of sepsis. The CDC 2018 guidelines have provided a vaccination regimen that should be offered to these patients as the standard of care. At UF Health, patients every month undergo splenectomy and splenic embolization but, to the best of our knowledge, there is no institutional protocol for vaccination and the administration of vaccination in these patients is not standardized. Some patients may not receive the recommended doses of timing of vaccines. The CDC recommends specific recommendations on which vaccines should be offered (Meningococcus ACWY, Meningococcus B, Pneumonococcus, Hemophilus Influenzae B) and when they should be given (14 days before or after surgery). This project is a quality improvement project from the departments of Hematology/Oncology and Medicine to improve adherence with national guidelines and standard of care for these patients regarding vaccination. This will be done by clinical audit and implementation of a decision-making tool and order panel in the electronic medical record.

QPI: Satish, Maharaj, (

Collaborators: Karan, Seegobin, (; Nisha, Tahiliani, (

Advisors: Lara, Zuberi, (

UF Health Big Aims: Reduce Variation None

MeSH Keywords: Embolization, Therapeutic, Splenectomy, Vaccination, Immunocompromised Host, Sepsis, Standard of Care