Project Information

Gathering Stakeholder Perspectives of the Implementation of Genotype-Guided Pain Management in Patients Undergoing Arthroplasty Surgery

Project Description: Genomic-guided interventions are new to routine medical practice, thus there is an increased need for research regarding the implementation of actionable genomics findings in patient care. To engage in successful implementations, researchers often follow the Consolidated Framework for Implementation Research (CFIR): Intervention Characteristics, Outer Setting, Inner Setting, Intervention Characteristics, and Process. The combination of these ideas forms a common framework or structure in which to develop implementations, many specifically important for genomics implementations. The Personalized Medicine Program in collaboration with the Department of Orthopaedics and Rehabilitation will be implementing a new genotype-guided pain management program in patients undergoing arthroplasty surgery. The program will be piloted this spring to test for the feasibility of this implementation and to evaluate its potential effects clinically. We hope to interview several key stakeholders (i.e orthopedic surgeons, pathology) to understand how the CFIR constructs are designed within this implementation at UF. With this understanding is ability to make decisions on improving the best practices for future pharmacogenomics implementation at UF in the Orthopedics and Rehabilitation Department and other clinical departments. For this quality improvement project, we will be interviewing the stakeholders prior to and after the intervention to evaluate both organizational readiness and barriers to a successful implementation.

QPI: Leanne, Dumeny, (


Advisors: (

UF Health Big Aims: Reduce Variation None

MeSH Keywords: Pharmacogenomic Testing, Orthopedic Surgeons, Analgesics, Opioid, Pain, implementation science