Project Information

Intraoperative NSAID use in patients with ESRD

Project Description: It is well known that NSAIDs can cause acute renal failure as well as worsen chronic kidney disease (CKD), however the effect of exposure in those with ESRD is not well described. In the perioperative setting, where pain management is of significant concern and with the goal of providing multimodal analgesia therapy, the use of NSAIDs is common. However, there is some data that shows that NSAIDs use in ESRD patients can impair residual renal function. The native kidneys in ESRD patient still play important filtration and endocrine function and life expectancy in ESRD patients is directly correlated to the preservation of residual renal function. Currently, there is no warning system in Epic that prompts providers to reconsider administering NSAIDs to patients with ESRD. The goal of this study is to first, determine a baseline for the incidence of NSAID administration in ESRD patients who are on chronic outpatient dialysis over a 6 month period. Then the next step would be to implement an intervention that would prompt providers to reconsider use of NSAIDs in those patients. The outcome will be assessed based on decrease in NSAID administration after intervention implementation.

QPI: Geoffrey, Panjeton, (

Collaborators: (; (

Advisors: (

UF Health Big Aims: Zero Harm None

MeSH Keywords: